Heralded as one of our country’s foremost comics, Paula Poundstone’s quick-thinking, unscripted approach to comedy makes for a perfect fit as a regular panelist on NPR’s #1 show, the screwball weekly news quiz show “Wait Wait…Don’t Tell Me!” where she holds the record for game losses. “The others cheat,” she says, magnanimously, “you wouldn’t think NPR would put up with that.” Ms. Poundstone tours regularly, performing her extemporaneous standup routines across the country. Her frequent interchanges with the audience are never mean or at a person’s expense. She even manages to handle politics, “…with the exception of that one time.” The talents of this brilliant humorist extend beyond standup comedy, but stop short of yodeling.